Analysis of data collected from 1725 9th graders from 25 rural high schools revealed that students reporting same-sex attraction or uncertainty about their attraction status also reported significantly lower GPAs, lower school belonging, and higher marijuana and alcohol use. Regression analyses confirmed that beyond the effects of GPA and biological sex, sexual minority attraction status was negatively associated with school belonging. Further, while higher school belonging significantly decreased the odds of alcohol and marijuana use, sexual attraction status did not significantly contribute to the model. Post-hoc analyses indicated that sexual minority students systematically reported that they perceived less privacy in completing the survey, lending support to the notion that these adolescents may feel less trusting of their school environments. These findings are discussed in light of the need for interventions to address the developmental challenges of sexual minority students.