This study examined the relationship between acculturation, perceived English fluency, social support, and depression among 112 graduate Taiwanese international students. Ordinary Least Squares analyses were conducted on 112 graduate Taiwanese international students from a university in southeastern United States. Results indicated that those individuals who were at risk of depressive feelings were more likely to be female Taiwanese students, low acculturated students, and students who have low perceived English fluency. An examination of potential mediating variables indicated that perceived English fluency mediated the effects of acculturation level on depression for both males and females.