Through a collaboration with a public school in a poor, urban, largely Latino neighborhood, a multisystemic program was designed to foster positive youth development and promote school success. Aspects of the program highlighted include (a) the rationale; (b) interventions developed with and for youth, their parents, and their teachers; (c) the process of incorporating cultural issues into the program; and (d) evaluation strategies. Recommendations for future program development are provided along with general ideas for program evaluation. (Contains 1 table.)