For postsecondary students with disabilities influencing reading performance, printed class materials pose a substantial barrier and have a negative impact on academic achievement. Digital technologies offer alternative ways of accessing print materials for students with print-related disabilities. Alternative media is a broad term that encompasses a variety of formats into which printed text is converted. "Alternative media", together with assistive computer technologies designed to read aloud the text, provide a means to access textual information and bypass the difficult reading process. The purpose of this article is to provide an overview of model programs and pertinent research on the use of alternative media by postsecondary students with print disabilities; we will identify promising practices for students whose disabilities negatively influence reading performance.