Screening for suicidality, as called for by the President's New Freedom Commission on Mental Health, is a major public health concern. As a place where adolescents spend a considerable amount of their waking hours, school is an important venue for screening adolescents for suicidal behaviors and providing preventive education and risk management. Social workers, as the largest occupational group of mental health professionals in the United States, have a significant role to play in the national strategy to prevent youth suicide, especially at the school level. This article reviews the literature on suicide prevention screening, warning signs, and risk factors to gain a better understanding of evidence-based screening strategies and discuss the implications for school social workers, counselors, and psychologists. It focuses on the identification of research-based information and explication of potential means for guiding preventive screening and clinical practice with suicidal adolescents.