The growing interest in the role that spirituality and religion play in mental health has spawned research investigating the relationships between spirituality, religion, and career development. To date, only a limited number of studies have explored these variables in tandem, but generally these investigations have found aspects of spirituality and religion to relate positively to career decision self-efficacy, career values, and job satisfaction. Theoretical models that explore the connection between these variables are outlined, and future research directions and counseling implications are suggested.