This study examines the perception of minority students underrepresented in the medical profession regarding educational and career barriers and to ascertain gender differences on their perceptions. A 30 item educational and career barriers inventory was administered to 97 underrepresented minority (URM) students enrolled in a special premedical education preparatory program. The results reveal that items viewed as possible barriers by the majority of students include: Medical College Admission Test (MCAT) scores, money problems, pressure to perform academically, negative stereotypes and ethnic discrimination in their future jobs. The majority of students (96%) feel they can overcome any barriers that stand in the way of career goal achievement. The sex discrimination subscale on the inventory produced the only significant gender differences. (Contains 3 tables.)