Trauma has the potential to undermine both the educational and personal achievement of students. This article will provide a review and an integration of theoretical and empirical literature on the prevention and treatment of stress disorders, particularly posttraumatic stress disorder (PTSD) in children and teens. An initial review of the biopsychosocial factors related to the development of stress disorders is followed by a comprehensive model of preventive intervention. Recommendations for best practices to prevent and treat PTSD in the school setting are guided by existing treatment-outcome literature. (Contains 1 table.)