Most UK Regional Development Agencies (RDAs) have committed themselves to developing an Enterprise Strategy for their region. This commitment is mainly in response to the current Labour government's keenness to see enterprise and entrepreneurship at the centre of any economic development agenda. Pro-entrepreneurship policies have been embraced as a means of generating economic growth and diversity, ensuring competitive markets, helping the unemployed to create jobs for themselves, countering poverty and welfare dependency, encouraging labour market flexibility and drawing individuals out of informal economic activity. The regional dimension of economic regeneration has been influenced, in part, by increasing interest in the local ramifications of national innovation and entrepreneurship policies, and also by growing awareness of the local or regional phenomenon of enterprise creation and innovation. The authors examine the connection between R&D activities in universities and the creation of new businesses (in particular ICT firms), and especially the role that social capital plays in fostering these relationships or connections. Preliminary empirical analyses suggest the importance of university-high-tech industry social capital in generating technology based start-ups. The findings suggest a case for fostering "connectedness" between research universities and high-technology firms in regions with interest in technology-based entrepreneurship. (Contains 9 figures and 3 tables.)