This article examines variations in patterns in the enactment of a large-scale kindergarten through Grade 12 science inquiry program. Student data reports in the GLOBE program provide a useful measure of implementation because key design elements in the program are student collection and reporting of local environmental data. We examined associations among teachers' responses to survey items to patterns in GLOBE data reporting to develop hypotheses about important contextual factors related to program implementation. Implications for the study of science inquiry programs are discussed.