Quantitative psychology is concerned with the development and application of mathematical models in the behavioral sciences. Over time, models have become more complex, a consequence of the increasing complexity of research designs and experimental data, which is also a consequence of the utility of mathematical models in the science. As models have become more elaborate, the problems of estimating them have become increasingly challenging. This paper gives an introduction to a computing tool called automatic differentiation that is useful in calculating derivatives needed to estimate a model. As its name implies, automatic differentiation works in a routine way to produce derivatives accurately and quickly. Because so many features of model development require derivatives, the method has considerable potential in psychometric work. This paper reviews several examples to demonstrate how the methodology can be applied.