Colleges are an important part of the creative sector. They offer what is all too rare: employment for artists, scientists, and other innovative thinkers in various disciplines; spaces to develop new work; and environments that ideally allow students and faculty members to experiment, take risks, and learn from their failures. One well-known example of how higher education can contribute to the creative economy is the partnership that Williams College built with the nearby city of North Adams to create the Massachusetts Museum of Contemporary Art, or Mass MoCA. A number of other colleges are participating in a new "creative campus" movement, thinking seriously about ways to enhance and harness their creative assets to be better educators and to support the communities where they are based and contribute to the creative economy through their talented students, faculty members, and administrators. This article discusses six challenges that colleges must strive to meet in order to contribute to cultural economic development.