Overall spiritual wellness, as well as 4 individual components of spiritual wellness, has been theoretically and empirically linked with depression. Prior to this investigation, no study has examined the relationship between spiritual wellness and depression by using a 4-component measurement model of spiritual wellness. In this study of older adolescents and midlife adults, negative correlations between 4 components of spiritual wellness and depression were found for both groups. Results of multiple regression analyses showed that for both older adolescents and midlife adults, the only significant contributing factor of spiritual wellness to depression was meaning and purpose in life. (Contains 2 tables.)