As a result of advances in GIS, students from a range of disciplines (epidemiology, public health, medical sociology, and anthropology) are seeking to learn how to apply a mapped, spatial perspective to issues of disease and health. This paper describes a pilot program whose intent has been to develop an interdisciplinary, skill-based course in medical mapping using a case-based approach. The focus of its first module is the famous nineteenth-century case of a cholera epidemic in Soho, London. Here, however, that case--critical to a range of disciplines--is an opportunity to introduce more GIS tools and their applicability to the issues surrounding the mapping of diseases in general.