Children's internalizing problems are a concerning mental health issue, due to significant prevalence and continuity over time. This study tested a multivariate model predicting young children's internalizing behaviors from parenting practices, parents' anxiety-depression and family stressors. A community sample of 2 year old children (N=112) was followed longitudinally to 4 years. Parents completed questionnaires and playroom observations provided independent measures of parenting and child variables. Predictors of early childhood internalizing difficulties were over-involved/protective parenting, low warm-engaged parenting, and parental anxiety-depression. Family life-stress and parental anxiety-depression also predicted problematic parenting practices. These findings were discussed within the context of the design of early childhood parenting programs to prevent anxiety and depression in children.