Teacher stress has attracted considerable attention, yet few studies have focused on special education teachers. This article, by Lambros Lazuras of the South-East European Research Centre (SEERC) in Thessaloniki, reports research designed to explore differences in the stress levels of general and special educators in Greece and provides preliminary evidence for a framework to understand the process of special education teacher stress. A total of 70 teachers from general and special education schools from a large Greek city participated in the study by completing questionnaires. Measures included occupational stress deriving from interpersonal conflict, organisational constraints, workload, work-related negative affectivity and health outcomes. Data analyses allowed for inferences regarding the dynamic interaction among the study variables. Findings appear interesting in terms of advancing current understanding of the relationships between different sources of job stress within the special education teaching context and provide general guidelines for future policies aiming to counter special education teacher stress.