This article describes a meta-analysis of the relationship between the Five-Factor Model of personality and smoking. The results, based on nine studies and a total of 4,730 participants, show that smoking was associated with the following five-factor traits: low conscientiousness, low agreeableness, and high neuroticism. Smokers outside Canada and the United States had significantly higher extraversion than nonsmokers, while extraversion was not significantly related to smoking in Canada and the United States. The results, which for the first time quantified precisely through meta-analysis the association between the five-factor model of personality and smoking, provide support for the relevance of the Five-Factor Model to an important behavior and for the trait element of Gilbert's (1995) Situation-Trait-Adaptation-Response model of smoking. The results also suggest possible avenues for smoking prevention and treatment and for further smoking research. (Contains 3 tables.)