The findings reported here emerged from a larger study of the social support networks and help-seeking experiences of low-income, Mexican-origin adolescents in San Diego, California. This larger study used a combination of qualitative and quantitative methodologies, and included special attention to those instances in which participating adolescents found in their friends the support necessary to withstand emotionally challenging circumstances (e.g., school-related problems) and to cope in effective ways. The analyses presented in this article highlight such instances but also examine those instances in which peer relationships failed to provide the safety and consistent support adolescents sought. Among the key findings, we describe how platonic (non-romantic) relationships between adolescent males and females emerged as an important avenue for acquiring the multiple and positive benefits of mature adolescent friendship (e.g., emotional support), particularly for the males. Study participants who reported platonic friendships also tended to report ample and diversified peer networks.