This article reviews cultural and methodological considerations when developing effective preventive interventions among Latino families. A prevention approach guides the discussion of five key issues in prevention science, including (a) the role of risk and protective factors, (b) fidelity and adaptation strategies, (c) program effectiveness, (d) methodological consideration, and (e) bridging prevention research and practice. An annotated bibliography complements our discussion of conceptual and methodological considerations and prevention and intervention practices when working with Latinos.