There is a clear need for improved math and science education, according to the National Institutes of Health, National Science Foundation, and National Science Board. The Food, Math and Science Teaching Enhancement Resource (FoodMASTER) Initiative was developed in response to this need. The FoodMASTER Initiative is a compilation of programs aimed at using food as a tool to teach science and math concepts. The initiative strives to enhance K-12 and higher education curricula by establishing collaborative efforts with university faculty and K-12 teachers. Although numerous concerns drove the implementation of this food-based math and science program, several factors led to the strategies initiated under the proposed plan. First, teachers often feel uncomfortable teaching science because of a lack of resources to support implementation of curricula and second, many K-12 students in the Appalachian region of the U.S. face barriers to attaining adequate academic performance because of poverty, which can stem from poor health. The FoodMASTER approach addresses these issues by directly focusing on math and science knowledge competencies of K-12 teachers and students, and integrating the much needed food, nutrition, and health information.