Reliability and validity of the Symptom Checklist 90 Revised (SCL-90-R) was investigated to determine if this instrument is appropriate for use with Hispanic college students. The sample (28 males, 177 females) consisted of 101 participants who identified as Anglo and 104 who identified as Hispanic (6 did not identify their ethnicity). Participants ranged in age from 17 to 50. Cronbach's alpha was used to assess each of the SCL-90-R's subscales. Multivariate analysis of variance (MANOVA) was employed to check for significant differences between Anglo and Hispanic students' pretest scores. The extent to which the SCL-90-R measures change in both samples in a similar way was investigated. The data support the reliability and validity of the SCL-90-R as a measure of psychological symptoms for Hispanic college students.