Although anxiety disorders represent the primary reason children and adolescents are referred for mental health services, children showing symptoms of these disorders are not easily recognized. School-based practitioners are in a unique position to help minimize the risk and prevent the development of anxiety disorders. This article examines the importance of early intervention and the applicability of the three-tiered prevention model to treat anxiety disorders. The three-tiered approach to preventive intervention distinguishes between universal, selected, and targeted levels of prevention. Examples of interventions for anxiety at each level of the model are described, and the role of school-based practitioners in implementing these interventions is discussed.