The Holistic Flow Model of Spiritual Wellness is a conceptualization of spiritual health and well-being that has implications for clinical practice and research. The model is unique in its placement of the spirit at the center of Life and in its fluid vision of the spirit. The authors present the model after a discussion of spirituality and the definitions of "flow" and a brief review of existing wellness models. The model's components are belief in a universal force, making meaning of life, making meaning of death, connectedness, faith, and movement toward compassion. Included in the article are descriptions of spirit, the components of spirituality, and a sample application of the model.