This research examined the effects of three factors (friendship, gender, and topic of teasing) on adolescents' predicted emotional reactions to hypothetical teasing episodes regarding appearance and academic competence. The 8th graders (n = 131) in Study 1 made predictions regarding the negative emotions and humor experienced when teasing occurred in a same-sex dyad of either friends or classmates. The 6th and 8th graders (n = 211) in Study 2 responded to hypothetical teasing interactions between same-sex or cross-sex dyads of friends or classmates. The results revealed that teasing by friends was interpreted with a more benevolent frame than that accorded to classmates. Overall, girls expected greater negative affect to result from the teasing than did the boys, especially when teasing was regarding weight. Although 8th graders reported more frequent teasing at school among same-sex peers, there were few grade differences in the predicted emotional reactions. For all students, teasing about weight was predicted to generate the most negative affect and least humor. The results support the relevance of the three factors for understanding the interpretation of teasing.