Multiple ecodevelopmental factors were tested as they influence suicidality in a community sample of Latino adolescent males. Risk factors tested included childhood maltreatment, parental alcohol-related problems, and polysubstance problems. Protective factors included general self-efficacy, social conformity, and family bonding. Male participants (N = 349) were recruited from the Los Angeles area. About 80% of the sample reported some suicidal ideation, and 26% reported a history of at least one suicide attempt. The strongest protective factor for suicidality was problem-solving confidence, followed by a good relationship with parents and being law abiding. The strongest risk factor for suicidality was emotional abuse, followed by hard drug use, mothers alcohol-related problems, and sexual abuse. Broad-based theories, research, treatment, and prevention efforts are critical to implement with this population.