This study examined the influence of psychosociocultural variables of acculturation, White attitudinal marginalization, family support, and income on perceived distress in 247 Mexican American female college students. Participants were bicultural and attended primarily White universities in the West and Southwest. Results showed that comfort with White cultural values, perceived support from family, and financial support are related to lower perceived distress for participants. Implications for counselors addressing perceived distress in Mexican American female college students are provided.