The use of microswitches has been considered a crucial strategy to help individuals with extensive multiple disabilities overcome passivity and achieve control of environmental stimulation (Crawford & Schuster, 1993; Gutowski, 1996; Ko, McConachie, & Jolleff, 1998). In recent years, considerable efforts have been made to extend the evaluation of microswitches and to make their role more relevant. For example, studies have investigated new, convenient responses and the matching microswitches that are likely to facilitate learning and performance with low-functioning persons and the possibility of using multiple microswitches for multiple responses to extend motor activity and sensory input (Lancioni et al., 2002). Responses to the environment by people with extensive multiple disabilities have almost exclusively involved simple motor acts, such as hand and head movements. However, vocal utterances may occasionally be present in a person's repertoire and could become crucial means of exerting control over environmental events (Lancioni, Singh, O'Reilly, & Oliva, 2003; Romski, Sevcik, & Adamson, 1999). To enable persons with severe multiple disabilities to reach the goal of using vocal utterances to control their environment, one would need microswitches that could discriminate between various utterances. Such microswitches do not exist. However, two computer systems were recently set up to substitute for such microswitches with one-syllable or wordlike utterances (Lancioni et al., in press). This study evaluated the system's setup for wordlike utterances (ones that could have a wider application in daily contexts) with two participants with multiple disabilities. The system combines a new control software program with a commercially available speech-recognition program (Dragon Naturally Speaking, V6.0 Standard, manufactured by Scansoft, 2002).