This study examined the use of popular culture-themed (PCT) courses in higher education. The goal was to define PCT courses operationally as well as qualitatively to explore benefits and challenges associated with teaching these courses. Instructors from a wide range of disciplines who have taught or are currently teaching a PCT course were asked about their experiences. A thematic analysis revealed seven benefits (for instance, they are fun) and seven challenges (for instance, it is difficult to find materials) to guide instructors in developing PCT courses. Strategies to mitigate these challenges are also discussed.