The flipped classroom is an innovative pedagogical strategy that can play a crucial role in the training of healthcare professionals, as soft skills are necessary competencies for the quality of patient care. This quasi-experimental study features a pre-test/post-test design, with a control group and an intervention group aiming to investigate the impact of flipped classrooms on the development of students' soft skills. The study involved 82 students from the Higher Institute of Nursing and Health Technical Professions of Agadir who participated in the first semester of the 2022-2023 academic year. The results indicated a significant increase (p < 0.001, d = 2.11 [1.56, 2.64]) in the averages of the 10 soft skills studied in the intervention group compared with the control group, as well as a significant difference in satisfaction (p = 0.003), participation in learning activities (p < 0.001), and the usefulness of extending the use of the flipped classroom to other training institutes (p < 0.001), thus showing a positive effect of the flipped classroom. This result encourages the use of this pedagogical strategy in modules that focus on soft skills, such as social assistance and psychological support.