The present cross-sectional study examined some of the factors associated with psychological distress among students enrolled in Bachelor's and Master's programs. We investigated the roles of age, academic performance, creativity, cognitive flexibility, educational mattering, and anti-mattering and their roles when discussing participants' psychological distress. Our sample comprised 337 students aged 19 to 29 from a Romanian public university, aged 19 to 29 (M = 20.86, SD = 1.55). Correlation analysis suggested that age, cognitive flexibility, educational mattering, and creativity were negatively related to students' psychological distress. Also, educational anti-mattering was positively linked to psychological distress. We did not find a significant link between students' psychological distress and academic performance. Further regression analysis suggested that educational anti-mattering was the strongest predictor of students' psychological distress. The practical implications of these findings are discussed concerning educational and psychological interventions that might contribute to decreased students' psychological distress.