Electronic cigarette use during middle school and high school has become an alarming public health concern. Educating youth about the risks of using e-cigarettes through a prevention program can be instrumental in curbing the growing numbers. Our Extension team implemented a prevention program, Escape Vapes, which adapted three Stanford University Tobacco Toolkit units. This study is an evaluation of the program that 1,347 youth in grades 5 through 12 completed. Results from the online retrospective post-pretest indicate that participation in the program significantly increased knowledge about e-cigarettes. Overall, the results indicate that Escape Vapes is an effective prevention program for increasing youths' knowledge.