To unpack the process of how health information seeking influences health behaviors, we examined the mediating roles of interpersonal discussion and online information sharing in the associations between health information seeking and healthy lifestyle behaviors and the moderating role of health literacy in the associations among health information seeking, interpersonal discussion, online information sharing, and healthy lifestyle behaviors. Data from a large-scale, representative survey (N = 916) revealed that interpersonal discussion and online information sharing mediated the associations between health information seeking and healthy lifestyle behaviors. The associations between health information seeking and interpersonal discussion and between health information seeking and online information sharing were stronger for individuals with high health literacy than those with low health literacy. Findings advance the understanding of the influence of health information seeking and provide practical guidance for promoting a healthy lifestyle.