Higher education faculty face an array of challenges in designing instruction to meet the needs of a diverse student population. Frameworks aligned with Universal Design (UD) have demonstrated effectiveness in meeting the needs of diverse learners and two frameworks, Universal Design for Learning (UDL) and Universal Design of Instruction (UDI), consistently appear in the higher education literature. To increase the likelihood of their use, guidance is necessary on how to use these frameworks to design effective instruction. A synthesized framework is proposed that focuses on crossover elements between UDL and UDI and instructional strategies aligned with both frameworks.