Professionals working in residential care homes for children and young people face challenges that affect their well-being at work and psychosocial climate. This study analyses the influence of work climate and psychosocial factors on the well-being of 164 workers in residential care centres in Spain, using the Psychosocial Climate at Work Scale (ECPT) and the FPSICO 4.1 questionnaire. Data analysis includes descriptive statistics, correlations and linear regressions to create predictive models. The results indicate that factors such as managerial role, experience in the social sector and external supervision contribute to a better psychosocial work climate. These findings highlight the importance of effective leadership from administrations and management teams, which favours a healthy environment for professionals. They also underline the need to establish staff retention mechanisms and to provide external supervision as additional support. Finally, it is recommended to implement socio-educational programmes focused on well-being at work that not only improve the psychosocial climate, but also increase the satisfaction and performance of workers, thus promoting an environment that favours the efficiency and well-being of the staff in residential care homes for children and young people.