Since colonization, Indigenous/Aboriginal Peoples (IAP) have fought for their inherent rights to follow their ways of life on their traditional territories. One continuing battle is the protection of sacred spaces. Sacred spaces are places recognized by IAP as deeply spiritually and powerful. Relationships to sacred spaces sustain spiritual connections integral to our concepts of holistic health/well-being and are vital for cultural integrity. Though all of the natural world is sacred to IAP, the particular cultural and spiritual significance of sacred spaces and impact on health merits attention. Drawing from qualitative research, this article investigates IAP's perspectives and experiences regarding the connection between Indigenous/Aboriginal and sacred spaces, and we conclude that the desecration of sacred spaces has negative impacts on IAP's health.