This research aimed to 1) study the relationship of factors affecting the adjustment of pre-service teachers in the Faculty of Education, Buriram Rajabhat University, and 2) study the factors affecting the adjustment of pre-service teachers in the Faculty of Education, Buriram Rajabhat University. The sample group consisted of 242 pre-service teachers from the Faculty of Education, Buriram Rajabhat University, selected by simple random sampling. The data collection tool was a 5-point Likert scale questionnaire. The statistics used for data analysis included mean, percentage, standard deviation, Pearson's correlation coefficient, and multiple linear regression analysis using the Stepwise method. Research findings revealed that 1) the relationship between the factors affecting the adjustment of pre-service teachers in the Faculty of Education, Buriram Rajabhat University had correlation coefficients ranging from 0.442 to 0.703, with all aspects showing statistical significance at the .01 level. The factors most related to adjustment were achievement motivation, followed by peer relationships, and attitude towards learning, respectively, and 2) the factors affecting the adjustment of pre-service teachers in the Faculty of Education that could predict their adjustment were: achievement motivation ([beta] = 0.496, b = 0.525), peer relationships ([beta] = 0.238, b = 0.221), and the relationship between mentor teachers and students ([beta] = 0.139, b = 0.118). These factors could predict the adjustment of pre-service teachers in the Faculty of Education, Buriram Rajabhat University, by 55.60% (R[superscript 2] = 0.556, p < 0.001). The predictive equation in unstandardized scores is Y = 0.461 + 0.525[subscript X2] + 0.221[subscript X4] + 0.118[subscript X5], and the predictive equation in standardized scores is Z[subscript Y]= 0.496Z[subscript X2] + 0.238Z[subscript X4] + 0.139Z[subscript X5].