Students with high incidence disabilities in the public school system often perform multiple grade levels below their typically developing peers in mathematics achievement. These students exhibit lower levels of on-task behavior that limits their access to effective instruction, thus requiring instructional interventions that personalize learning, differentiate materials, and ultimately promote academic engagement. In recent years, the use of technology-mediated and computer-assisted instruction has shown to have positive results with students with disabilities. Blended learning, an intervention that combines face-to-face instruction with computer-based instruction, has been shown to improve the on-task behavior and achievement of students with disabilities. In this study, blended learning was implemented with three middle school students with emotional behavior disorders in a therapeutic setting in a large city in the southeastern United States. Using a multiple baseline across participants single case design, this study examined the relationship between blended learning eighth grade mathematics instruction and student on-task behavior, teacher engagement, and mathematics achievement. After exposure to the intervention through 21 sessions over 5 weeks, both student and teacher engagement increased with the use of station-rotation blended learning. Math achievement, measured through the AIMSweb curriculum-based math probes, improved for two of three student participants. Social validity questionnaires revealed that students and teacher enjoyed the blended learning intervention; however, continued use depended on properly functioning technology. Future research in the area of blended learning math instruction should strive to accurately measure on- and off-task behavior under the computer-based condition.