This article reviewed published research on implementing the Response to Intervention (RTI)/Multi-tiered Systems of Support (MTSS) educational framework in mathematics at public schools. Today, all 50 states have adopted different forms of the tiered educational system, and the focus of these support systems is switching from model building to implementation. Currently, no literature has reviewed research in mathematics RTI/MTSS implementation practice at school. We utilized the Implementation Drivers framework to analyze current practices to fill this gap and promote scientific implementation. We also provided a context-based facilitator and barrier analysis to support researchers and stakeholders in understanding real-world practice. Findings showed that more research is needed to expand the investigations in Implementation Fidelity, Systems Intervention, Facilitative Administration, Decision-Support Data Systems, Coaching, and Selection.