This study examines the correlation between youngsters' media literacy and their trust in government, support for anti-pandemic regulations, and vaccine readiness during the COVID-19 pandemic in Vietnam. The findings show a statistically significant positive correlation between youngsters' media literacy and their trust in government, support for anti-pandemic regulations, and vaccine readiness. The more media literacy youngsters have, the more likely they trust the government, comply with anti-pandemic regulations, and take the COVID-19 vaccines. The findings emphasize the importance of media literacy and media literacy education as the core solution to construct a media-literate society, in which youngsters use media for their personal growth and social development. In such aspect, media literacy can be an effective tool to manage the pandemic and a type of social vaccine to end the infodemic.