This meta-analysis examined 12 empirical studies, published from 2013 to 2023, to determine the effectiveness of DBL in enhancing scientific creativity. The sample size involved 1211 students. Based on the analysis using random-effect model, DBL has a positive and strong significant effect (ES=1.181) to scientific creativity. Moderator analysis uncovered significant difference in the effect sizes when clustered according to the academic level and geographic location, while the STEM discipline and the implementation period demonstrated otherwise. It is further revealed that engineering design (g=1.546) registered the largest effect size in comparison with design thinking (g=0.896) and STEAM design (g=0.696) models. Moreover, originality, elaboration, fluency, and flexibility are the most frequently used dimensions in assessing scientific creativity. In conclusion, the findings established the effectiveness of DBL in enhancing scientific creativity among STEM students. Hence, teachers must be equipped of the technical knowhow of integrating design process in teaching STEM subjects.