Integrated STEM learning is an appropriate approach to improve students' abilities and skills needed in the 21st century. Therefore, this literature study aims to discuss the effectiveness of integrated STEM implementation in science learning. The focus of this research includes integrated STEM implementation, effectiveness, and analysis of abilities and skills that can be improved through STEM integration. The method used in this literature study is a Systematic Literature Review, which includes several stages, namely Identification, Screening, and Included. The databases used include Springer, Taylor & Francis, ERIC, and Google Scholar. This literature review article is limited to the last 8 years, from 2016 to 2023. After screening, 35 articles were obtained, which were used as literature material regarding the effectiveness of integrated STEM learning in science. The results of the study show that STEM implementation can be integrated with various learning models such as PjBL, PBL, Jigsaw, 5E-EDP, and 6E-Cycle. In addition, it can also be integrated with media, including interactive video, virtual labs, and mobile augmented reality. Integrated STEM has proven to be effective in improving students' abilities and skills. The student's abilities and skills include 4C skills, concept understanding and cognitive abilities, motivation, ICT and computational literacy, spatial and geographic thinking skills, and mathematical thinking skills.