Cyberinfrastructure (CI) empowers the foundational computation resources underlying data analytics, spatial modeling, and many other domains serving the growing knowledge economy in the United States. In every part of these interactions with CI, questions of how to seamlessly integrate CI training into educational programs exist. In this article, the authors present results from a project that addresses the lack of experience using the integrated tools and techniques necessary to address crucial global challenges requiring domain and CI integrations for learners, instructors, and researchers. The authors created a clear curriculum model for educators, the Hour of Cyberinfrastructure (Hour of CI), which integrates CI knowledge and skill-building into a domain-specific curriculum.