Technology has revolutionised how we interact, work, and learn, with digital literacy offering lifelong learning opportunities. College students heavily rely on the Internet for education. As more students with developmental difficulties enter higher education, it is vital to understand how disparities impact classroom learning. This study assesses online inquiry and research skills in college students with reading difficulties compared to those with typical reading skills. We recruited 67 college students, including those with reading difficulties, in online research about the ketogenic diet, responding to open-ended questions. Findings reveal that students with reading difficulties could access basic information online like their peers but encountered challenges in identifying critical data, explaining concepts, describing processes, and constructing resource-based arguments. This study underscores the importance of educational assessments to enhance digital literacy among college students with reading difficulties, with implications for instruction and future research.