In the twenty-first-century working professionals need to possess strong Interactional Competence to handle professional communication in intercultural contexts (PCIC). However, the relationship among the three PCIC constituents -- culture, workplace and interaction -- is undertheorized in current research. This leaves PCIC practitioners oftentimes uncertain of how to better define and develop their communication skills. This article seeks to address the gap by first analysing the two dominant PCIC epistemologies: the inference-based, psychological-positivist approach and the practice-based, interactional-constructivist approach. I then propose an analytical PCIC framework to differentiate the "inference" we make about one another and the "practice" we observe in each other. Using authentic PCIC training materials analysed through Sequential-Categorial Analysis (combining Conversation Analysis and Membership Categorization Analysis), I argue the concept of Interactional Competence can bridge inference and practice, offering a route to assisting researchers in analysing PCIC, educators in developing PCIC training materials, and practitioners in refining their PCIC skills. Pedagogical applications of the PCIC framework are also presented. I conclude the paper with theoretical, methodological and practical implications for PCIC, where we constantly see grounds for inclusion and exclusion articulated around notions of culture and professional identities.