Being able to understand, interpret, and critically evaluate data is necessary for all individuals in our society. Using the PreK-12 Guidelines for Assessment and Instruction in Statistics Education-II (GAISE-II; Bargagliotti et al., 2020) curriculum framework, the current paper outlines five evidence-based recommendations that teachers can use to build understanding of statistical investigation and data analysis for students with mathematics difficulties, including: (1) Explicitly teach important vocabulary related to statistical investigation and data analysis, (2) Introduce the steps and purpose of statistical investigation, (3) Guide students through the statistical investigation process, (4) Link investigative questions to word problem types to solve, and (5) Build understanding of variability throughout.