Limited research is available on the acceptability of comprehensive sex education for economically marginalized Black youth. The current evaluation study collected quantitative self-report data from 109 high-school-aged predominately Black or African American economically marginalized youth after completing a comprehensive sex education program. Youth reported positive experiences with the program, improvement in socioemotional skill development, and increases in sexual risk avoidance behavior. Youth report of quality of experience predicted youth sexual risk avoidance. These findings serve as evidence for tailoring comprehensive sex education programs to youth demographic variables.