K-12 education as an enterprise always has two main aims; to teach basic skills and knowledge and to cultivate moral citizenry. There is substantial evidence that empathy can promote morality and character development through education. To shed light on what has been done and to identify the pathways already established, a thematic review of research focused on empathy development in K-12 science education has been conducted. A systematic examination of literature published before January 2024 resulted in 28 publications being analyzed in terms of their general characteristics and the specifics of the designed interventions. Results show that educational interventions can improve empathy skills; these studies use collaborative learning environments, take 3-10 weeks to implement, and the most preferred strategy is recognizing different perspectives of a given situation with reflective exercises. All of the studies reviewed positively affected students' affective and cognitive domains. For future research, more interventions designed to improve empathy skills in parallel with the science curriculum are proposed to supply teachers with new comprehensive resources to implement.