Career shocks can significantly impact individuals' career development. We propose that how a career shock affects career development depends on how people appraise it. Specifically, our Career Shock Coping (CSC) model proposes that, dependent on personal characteristics, individuals differ in the extent to which they appraise career shocks as challenging and/or threatening. Challenge and threat appraisals inspire approach- and avoidance-oriented career behaviors, respectively, which differentially relate to career-related outcomes. A two-wave study was conducted among medical students (N = 279) in the context of the COVID-19 pandemic as a career shock. Supporting our CSC model, core self-evaluation (CSE) related negatively to threat appraisal and threat appraisal related positively to avoidance-oriented career behavior. Avoidance-oriented career behavior related positively to career decision-making stress. The relations between CSE, challenge appraisal, approach-oriented career behavior, and career decision-making stress were not significant. The findings have implications for career shocks research and career counseling practice.