Educational inclusion aims to support all students through instructional and contextual designs that promote learning. Educators are assigned the task of teaching an increasingly neurodiverse population with varying neurological processes and perceptions. Traditional school-based settings are designed for individuals with less neurodivergence, and, therefore, may not adequately facilitate an environment supportive of learning for all students. Additionally, neurodiverse learners, including those with autism, may have sensory processing differences that impact occupational participation and performance. Understanding the processing differences of neurodivergent students and interventions that support those needs may facilitate successful inclusion programs. Research and data analysis confirmed the "Ready to Learn and Play (RtLP)" as an evidence-based framework to facilitate participation and performance for individuals with neurodiversity and sensory processing challenges, both for in-person (statistical significance p = 0.001) and virtual presentation of the "RtLP" content (statistical significance p = 0.00000607). Through a neuroaffirming approach to teaching, coaching, and training, "RtLP" may assist in supporting individuals with sensory regulation challenges to participate to the greatest extent possible in inclusive education.