This study aims to explore the difference between on-line and off-line teaching and comprehensively evaluate the of elearning system operation effect as both technology-mediated learning and an open information system. This study develops "process-situation-result" (PSR) network, a comprehensive learning system evaluation model. It empirically analyzes the PSR models under off-line and on-line teaching, as well as the intermediary role of e-learning situation in the impact of e-learning process on elearning results. The results show: (1) Learners' perception of e-learning situation is obviously different between off-line and on-line teaching. (2) The eight dimensions of e-learning process have no significant direct impact on e-learning outcome Except in on-line teaching groups, SF (getting self-feedback) has a significantly positive influence. In off-line teaching, GA (gaining attention), IO (informing learner of the objectives), and PG (providing learning guidance) have indirect effects on e-learning. (3) GA, IO and PG have a direct impact on e-learning situation in both on-line and off-line teaching, and only RK (Stimulating recall of prior knowledge) has an impact only in on-line teaching. The other four dimensions have no direct impact on e-learning We provide a theoretical framework for the integration of technology and teaching, on-line teaching and off-line teaching.